Publications

  1. Nödling, A.; Świderek, K.; Castillo, R.; Hall, J.W.; Angelastro, A.; Morill, L.C.; Jin, Y.; Tsai, Y.-H.; Moliner, V.*; Luk, L.Y.P.* Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host. Angewandte Chemie Int. Ed. (2018). accepted.
  2. Suzuki, T.; Asami, M.; Patel, S.G.; Luk, L.Y.P.; Tsai, Y.-H.; Perry, A.C.F. Switchable Genome Editing via Genetic Code Expansion. Sci. Rep. 8, 10051 (2018). DOI: 10.1038/s41598-018-28178-3
  3. Behiry, E.M.; Ruiz-Pernia, J.J.; Luk, L.Y.P.; Tuñón, I.; Moliner, V.; Allemann, R.K. Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State. Angew. Chem. Int. Ed., 57, 3128–3131 (2018). DOI:10.1002/anie.201712826
  4. Świderek, K.; Nödling, A.; Tsai, Y-H.; Luk, L.Y.P.*; Moliner, V.* The Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effect. J. Phys. Chem. A. 122, 451-459 (2017). DOI: 10.1021/acs.jpca.7b118039
  5. Liao, J.H.; Tsai, C-H.; Patel, S.G.; Yang, J.T.; Tu, I-F.; Cicero, M.L.; Lipka-Lloyd M.; Wu, W-L.; Shen, W-J.; Ho, M-R.; Chou, C-C.; Sharma, G.R. Okanishi, H.; Luk, L.Y.P.; Tsai, Y-H.; Wu, S-H. Acetylome of Acinetobacter baumannii SK17 a highly conversed modification of histone-like protein HU. Mol. Biosci. 4, 1-12 (2017). DOI: 10.3389/fmolb.201700077
  6. Angelastro, A.; Dawson, W.D.; Luk, L.Y.P.; Loveridge, E.J.; Allemann, R.K. Chemoenzymatic Assembly of Isotopically Labeled Folates. J. Am. Chem. Soc., 139, 13047–13054 (2017). DOI: 10.1021/jacs.7b06358
  7. -J. Lai, I-F. Tu, W.-L. Wu, J.-T. Yang, L. Y. P. Luk, M.-C. Lai, Y.-H. Tsai, S.-H. Wu, Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance. BMC Microbiol. 25, 123 (2017). DOI: 10.1186/s12866-017-1034-2
  8. Wilkins, L.C.; Santi, N.; Luk, Y.P.; Melen, R.L. Reactions of biologically inspired hydride sources with B(C6F5)3. Phil. Trans. R. Soc. A. 28, 20170009 (2017). DOI: 10.1098/rsta.2017.0009
  9. Scott, A.F.; Luk, L.Y.P.; Allemann, R.K. Chemical ligation and isotope labeling to locate dynamic effects. Methods in Enzymology. 596, 23-41 (2017). DOI: 10.1016/bs.mie.2017.06.040
  10. Loveridge, E.J.; Hroch L.; Hughes, R. L,; Williams T.; Davies, R.L.; Angelastro, A.; Luk, Y.P.; Maglia, G.; Allemann, R.K. Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima. Biochemistry, 56, 1879–1886 (2017), DOI: 10.1021/acs.biochem.6b01268
  11. Angelastro, A.; Dawson, W.D.; Luk, Y.P.; Allemann, R.K. A versatile disulfide-driven recycling system for NADP+ with high cofactor turnover number. ACS Catalysis, 7, 1025–1029 (2016), DOI: 10.1021/acscatal.6b03061
  12. Castillo, J.P.; Sánchez-Rodríguez, J.E.; Hyde, H.C.; Zaelzer, C.A.; Aguayo, D.; Sepúlveda, R.V.; Luk, L.Y.P.; Kent, S.B.H.; Gonzalez-Nilo, F.D.; Bezanilla, F.; Latorre, R.; β1-subunit–induced structural rearrangements of the Ca2+– and voltage-activated K+ (BK) channel. Proc. Natl. Acad. Sci. 113, E3231–E3239, (2016) DOI: 10.1073/pnas.1606381113
  13. Ruiz-Perniaa, J.J.; Behiry, E.; Luk, L.Y.P.; Loveridge, E.J., Tuñónc, I., Moliner, V.; Allemann, R.K.; Minimization of Dynamic Effects in the Evolution of Dihydrofolate Reductase. Chemical Sci. 7, 3248-3255 (2015). DOI:10.1039/C5SC04209G
  14. Luk, L.Y.P.; Ruiz-Pernia, J.J.; Adesina, A.S.; Loveridge, E.J.; Tuñón, I.; Moliner, V.; Allemann, R.K.; Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase. Angew. Chem. Int. Ed., 54, 9016-9020 (2015). DOI: 10.1002/anie.201503968
  15. Luk, L.Y.P.; Loveridge, E.J.; Allemann, R.K.; Protein motions, Dynamic effects and Thermal stability in Dihydrofolate Reductase from the hyperthermophile Thermotoga maritima, book chapter, pp 99-113, Springer.
  16. Luk, L.Y.P.; Loveridge, E.J.; Allemann, R.K.; Protein Motions and Dynamic Effects in Enzyme Catalysis. Phys. Chem. Chem. Phys., 17, 30817-30827 (2015). DOI: 10.1039/c5cp00794a.
  17. Luk, L.Y.P.; Ruiz-Pernía, J.J.; Dawson, W.M.; Loveridge, E.J.; Tuñón, I.; Moliner, V.; Allemann, R.K.; Protein Isotope Effects in Dihydrofolate Reductase from Geobacillus stearothermophilus show Entropic-enthalpic Compensatory Effects on the Rate Constant. J. Am. Chem. Soc. 136, 17317-17323 (2014). DOI: 10.1021/ja5102536
  18. Guo, J.; Loveridge, E.J.; Luk, L.Y.P.; Allemann, R.K.; Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus. Biochemistry, 53, 2855-2863 (2014). DOI: 1021/bi500238q
  19. Behiry, E.M.; Luk, L.Y.P.; Matthews, S.M.; Loveridge, E.J.; Allemann, R.K.; Role of the Occluded Conformation in Bacterial Dihydrofolate Reductases. Biochemistry, 53, 4761-4768 (2014) DOI: 1021/bi508507v
  20. Luk, L.Y.P.; Loveridge, E.J.; Allemann, R.K.; Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases, J. Am. Chem. Soc., 136, 6862-6865 (2014) DOI: 10.1021/ja502673h
  21. Luk, L.Y.P.; Ruiz-Pernia, J.J.; García-Meseguer, R.; Marti, S.; Loveridge, E.J.; Tuñón, I.; Moliner, V.; Allemann, R.K.; Increased Dynamic Effects in a ‘Dynamic Knockout’ of Dihydrofolate Reductase from Escherichia coli, J. Am. Chem. Soc., 135, 18689-18696 (2013) DOI: 10.1021/ja410519h
  22. Luk, L.Y.P.; Ruiz-Pernia, J.J.; Dawson, W.M.; Roca, M.; Loveridge, E.J.; Glowacki, D.R.; Harvey, J.N.; Mulholland, A.J.; Tuñón, I.; Moliner, V.; Allemann, R.K.; Unravelling the role of Protein Dynamics in Dihydrofolate Reductase Catalysis, Proc. Natl. Acad. Sci., 110, 16344-16349 (2013) DOI: 10.1073/PNAS.1312437110
  23. Guo, J.; Loveridge, E.J.; Luk, L.Y.P.; Allemann, R.K.; Effect of Dimerization on Catalysis by Dihydrofolate Reductase, Biochemistry, 52, 3881-3887 (2013) DOI: 10.1021/bi4005073
  24. Mahmoodi, N.; Qi, Q.; Luk, L.Y.P.; Tanner, M.E.; Rearrangements in the Mechanisms of the Indole Alkaloid Prenyltransferases, Pure Appl. Chem., 85, 1935-1948 (2013). DOI: 10.1351/PAC-CON-13-02-02
  25. Luk, L.Y.P.; Qian, Q.; Tanner, M.E.; A Cope Rearrangement in the Reaction catalyzed by Dimethylallyltryptophan Synthase? J. Am. Chem. Soc. 133, 12342-12345 (2011); DOI: 10.1021/ja2034969
  26. Luk, L.Y.P.; Tanner, M.E.; Mechanism of Dimethylallyltryptophan Synthase: Evidence for a Dimethylallyl Cation intermediate in an Aromatic Prenyltransferase reaction, J. Am. Chem. Soc. 131, 13932-13933 (2009); DOI: 10.1021/ja906485u
  27. Luk, L.Y.P.; Bunn, S.; Liscombe, D.K.; Facchini, P.J.; Tanner, M.E.; Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction, Biochemistry, 46, 10153-10161 (2007); DOI: 10.1021/bi700752n
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